Pressor Responses to Noxious Stimuli in Hypertensive Patients
نویسندگان
چکیده
IN previous studies, pressor reactivity to several standardized noxious stimuli was evaluated quantitatively, and increased responsiveness was demonstrated in hypertensive as compared with normotensive subjects." 2 The stimuli employed in these studies included simple psychologic provocation as well as the cold pressor test and the intravenous injection of a small dose of angiotensin II. Differences in the physiologic mechanisms of response were suggested from examination of the influence of diabetes mellitus on pressor reactivity to these stimuli.2 Since alteration by hypotensive drugs of the blood pressure response to noxious stimuli represents a clinically important but usually undetermined pharmacologic function, evaluation of the effect of several of these agents also was undertaken. In an earlier study it was reported that chlorothiazide and reserpine, in their usual therapeutic doses in hypertensive patients, failed to diminish the degree of pressor response to several of the aforementioned stimuli, despite lowering of the basal pressure.3 The present study was designed to test the reactivity of hypertensive patients before and during therapy with two more potent hypotensive agents, guanethidine sulfate and alpha methyldopa. The data also were examined for information pertinent to the questions of the clinical pharmacology and mechanism of action of these compounds.
منابع مشابه
Pressor responses to noxious stimuli in hypertensive patients. Effects of reserpine and chlorothiazide.
CLINICALi STUDIES of hypotensive drugs have been concerned primarily with the effects of these agents on basal or casual levels of blood pressure. Little attention has been given to alterations in the reactivity of the blood pressure to noxious stimuli during the course of chronie drug therapy. Persistent reactivity in treated patients is iiuplied fronm such data as those indicating that blood ...
متن کاملEffects of practolol on pressor responses to noxious stimuli in hypertensive patients.
IN previous studies, pressor reactivity to several standardized noxious stimuli was evaluated quantitatively, and increased responsiveness was demonstrated in hypertensive as compared with normotensive subjects." 2 The stimuli employed in these studies included simple psychologic provocation as well as the cold pressor test and the intravenous injection of a small dose of angiotensin II. Differ...
متن کاملPressor Responses to Noxious Stimuli in Hypertensive Patients: Effects of Guanethidine Sulfate and Alpha Methyldopa.
متن کامل
Studies in man on the relationship of adrenergic correlates to pressor responsivity.
THE PRESENT STUDY was undertaken as part of a continuing investigation of the mechanisms of cardiovascular responsiveness to noxious stimuli.' Its purpose was to determine (1) whether stimuli which raise blood pressure in man would produce concomitant changes in biochemical measures of activation of the autonomic nervous system, (2) whether such changes would vary with different stimuli, and (3...
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Background: Tracheal intubation and direct laryngoscopy are powerful noxious stimuli that can elicit sever hemodynamic responses. These hemodynamic responses should be attenuated by appropriate use of premedication, smooth induction of anesthesia and rapid tracheal intubation. Gabapentin and pregabalin have been suggested in several studies to be efficient. Gabapentin is an antiepileptic drug a...
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تاریخ انتشار 2005